Article
Is the Solution Dilution? Hidden Uncertainty in Gas Chromatography (GC) Methods
LCGC North America
(2022)
Abstract
Used by chemists and nonchemists alike, gas chromatography (GC) is considered mature and among the most widely used instrumental techniques for chemical analysis. Because instruments have become both more sensitive and easier to use, columns have achieved higher resolution and stationary phases have greater selectivity. As a result, gas chromatographs have taken on a “black box” view. With greater sensitivity, resolution, and advanced data handling capabilities, a new set of experimental uncertainties emerge that may not be apparent to most users, especially those who were not formally trained as analytical chemists. In this installment of ”GC Connections,” we examine these uncertainties in typical GC methods, especially as they relate to quantitative analysis. We look at hidden experimental uncertainty, especially in the glassware used for sample preparation. We also comment on injection and detection with an eye toward understanding the sources of the errors. It is important to understand the experimental error and uncertainty are inherent in all analytical techniques; they can be reduced but cannot be eliminated.
Disciplines
Publication Date
July, 2022
Citation Information
Nicholas Snow. "Is the Solution Dilution? Hidden Uncertainty in Gas Chromatography (GC) Methods" LCGC North America Vol. 40 Iss. 7 (2022) p. 304 - 308 ISSN: 0888-9090 Available at: http://works.bepress.com/nicholas_snow/75/