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High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments
Journal of Magnetic Resonance (2020)
  • Jason G. Skinner, University of Nottingham
  • Kaili Ranta, Southern Illinois University Carbondale
  • Nicholas Whiting, Rowan University
  • Aaron M. Coffey, Vanderbilt University Medical Center
  • Panayiotis Nikolaou, XeUS Technologies LTD, Pano Lakatamia, Nicosia 2312, Cyprus.
  • Matthew S. Rosen, Harvard University
  • Eduard Y. Chekmenev, Russian Academy of Sciences
  • Peter G. Morris, University of Nottingham
  • Michael J. Barlow, University of Nottingham
  • Boyd M. Goodson, Southern Illinois University Carbondale
Abstract
Spin-exchange optical pumping (SEOP) can enhance the NMR sensitivity of noble gases by up to five orders of magnitude at Tesla-strength magnetic fields. SEOP-generated hyperpolarised (HP) 129Xe is a promising contrast agent for lung imaging but an ongoing barrier to widespread clinical usage has been economical production of sufficient quantities with high 129Xe polarisation. Here, the ‘standard model’ of SEOP, which was previously used in the optimisation of continuous-flow 129Xe polarisers, is modified for validation against two Xe-rich stopped-flow SEOP datasets. We use this model to examine ways to increase HP Xe production efficiency in stopped-flow 129Xe polarisers and provide further insight into the underlying physics of Xe-rich stopped-flow SEOP at high laser fluxes.
Publication Date
January 16, 2020
DOI
10.1016/J.JMR.2020.106686
Citation Information
Jason G. Skinner, Kaili Ranta, Nicholas Whiting, Aaron M. Coffey, et al.. "High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments" Journal of Magnetic Resonance Vol. 312 (2020) p. 106686
Available at: http://works.bepress.com/nicholas-whiting/25/