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The Drosophila IMD pathway in the activation of the humoral immune response
Infectious Diseases and Immunology Publications and Presentations
  • Anni Kleino, University of Massachusetts Medical School
  • Neal S. Silverman, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Infectious Diseases and Immunology
Date
1-1-2014
Document Type
Article
Abstract
The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria. During the last two decades, significant progress has been made in identifying the components and deciphering the molecular mechanisms underlying this pathway, including the means of bacterial sensing and signal transduction. While these findings have contributed to the understanding of the immune signaling in insects, they have also provided new insights in studying the mammalian NF-kappaB signaling pathways. Here, we summarize the current view of the IMD pathway focusing on how it regulates the humoral immune response of Drosophila.
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Citation: Kleino A, Silverman N. The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol. 2014 Jan;42(1):25-35. doi:10.1016/j.dci.2013.05.014. Link to article on publisher's site

Related Resources
Link to Article in PubMed
Keywords
  • Immune response,
  • NF-κB signaling,
  • Drosophila
PubMed ID
23721820
Citation Information
Anni Kleino and Neal S. Silverman. "The Drosophila IMD pathway in the activation of the humoral immune response" Vol. 42 Iss. 1 (2014) ISSN: 0145-305X (Linking)
Available at: http://works.bepress.com/neal_silverman/60/