|Present||Associate Professor of Chemistry, Cedarville University ‐ Department of Science and Mathematics|
- Chemical Research
- Chemistry for Engineers
- General Chemistry
- Organic Chemistry
- Principles of Physical Science
Department of Science and Mathematics
Part 1: Synthesis of Psico-nucleoside Analogs of Oxetanocin A. Part 2: Synthesis of Alpha-glycosphingolipids for in Vivo Studies and Purity Determination Faculty Dissertations (2010)
Oxetanocin A, isolated in 1986 from the fermentation broth of Baccilus megaterium , was the first reported, naturally occurring nucleoside that contained an oxetane as the sugar moiety. This novel nucleoside also demonstrated potent anti-viral ...
Recent Works (1)
Book Chapters (1)
Refereed Journal Articles (3)
Access to Oxetane-containing psico-Nucleosides from 2-Methyleneoxetanes: A Role for Neighboring Group Participation? The Journal of Organic Chemistry (2011)
The first psico-oxetanocin analog of the powerful antiviral natural product, oxetanocin A, has been readily synthesized from cis-2-butene-1,4-diol. Key 2-methyleneoxetane precursors were derived from beta-lactones prepared by the carbonylation of epoxides. F+-Mediated nucleobase incorporation provided ...
A CD1d-Dependent Antagonist Inhibits the Activation of Invariant NKT Cells and Prevents Development of Allergen-Induced Airway Hyperreactivity The Journal of Immunology (2010)
The prevalence of asthma continues to increase in westernized countries, and optimal treatment remains a significant therapeutic challenge. Recently, CD1d-restricted invariant NKT (iNKT) cells were found to play a critical role in the induction of ...
Design and Synthesis of an Activity-Based Probe Template for Protein Kinases Synlett (2010)
A potential activity-based probe for protein kinases was designed around mechanism-based inhibitors of insulin receptor kinase. The probe was synthesized by a chemoselective conjugate addition of ATPγS to an epoxyenone.