Access to Oxetane-containing psico-Nucleosides from 2-Methyleneoxetanes: A Role for Neighboring Group Participation?
(Yanke Liang, Nathan E. Hnatiuk, John M. Rowley, et al.)
The Journal of Organic Chemistry
(2011)
The first psico-oxetanocin analog of the powerful antiviral natural product, oxetanocin A, has been readily synthesized from cis-2-butene-1,4-diol. Key 2-methyleneoxetane precursors were derived from beta-lactones prepared by the carbonylation of epoxides. F+-Mediated nucleobase incorporation provided ...