Long-Term Outcomes for Children with Very Early-Onset Colitis: Implications for Surgical ManagementJournal of Pediatric Surgery (2018)
The timing of J-pouch surgery following colectomy for children with very early-onset colitis is controversial, with some advocating early reconstruction and others delaying reconstruction because of fear that the colitis may be owing to Crohn's disease (CD). We sought to determine the long-term incidence of CD in this population and whether there may be clinical features that predict the risk of CD.
Children with noninfectious colitis diagnosed prior to age 10, who underwent subtotal colectomy and ileostomy from 2000 to 2015, were reviewed.
Twenty-five children were identified. Median age at presentation was 5.4 years. Four were initially diagnosed with CD (16%), 14 with ulcerative colitis (UC) (56%), and 7 with inflammatory bowel disease unclassified (IBD-U) (28%). Eight eventually had pouch surgery. Five of the children with an initial diagnosis of UC or IBD-U developed findings that changed the diagnosis to CD at a median age of 13.4 (range 10.3 to 16.7) years. None had any indicators of CD at the initial presentation.
Approximately one quarter of patients with very early-onset colitis originally diagnosed as UC or IBD-U had a reclassification in diagnosis to CD over time. J-pouch reconstruction should be delayed until adolescence in children with very early-onset colitis.
Citation InformationKristy L Rialon, Eileen Crowley, Natashia Seemann, Aodhnai S Fahy, et al.. "Long-Term Outcomes for Children with Very Early-Onset Colitis: Implications for Surgical Management" Journal of Pediatric Surgery (2018)
Available at: http://works.bepress.com/natashia-seemann/2/