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Article
Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines
Materials
  • Handan Acar, Iowa State University
  • Saikat Banerjee, Iowa State University
  • Heliang Shi, Iowa State University
  • Reihaneh Jamshidi, Iowa State University
  • Nicole N. Hashemi, Iowa State University
  • Michael W. Cho, Iowa State University
  • Reza Montazami, Iowa State University
Document Type
Article
Publication Date
4-1-2016
DOI
10.3390/ma9050321
Abstract
Polymer-based interpenetrating networks (IPNs) with controllable and programmable degradation and release kinetics enable unique opportunities for physisorption and controlled release of therapeutic proteins or vaccines while their chemical and structural integrities are conserved. This paper presents materials, a simple preparation method, and release kinetics of a series of long-term programmable, biocompatible, and biodegradable polymer-based IPN controlled release platforms. Release kinetics of the gp41 protein was controlled over a 30-day period via tuning and altering the chemical structure of the IPN platforms. Post-release analysis confirmed structural conservation of the gp41 protein throughout the process. Cell viability assay confirmed biocompatibility and non-cytotoxicity of the IPNs.
Comments

This is an article from Materials 9 (2016): 321, doi: 10.3390/ma9050321. Posted with permission.

Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
Copyright Owner
The Authors
Language
en
File Format
application/pdf
Citation Information
Handan Acar, Saikat Banerjee, Heliang Shi, Reihaneh Jamshidi, et al.. "Transient Biocompatible Polymeric Platforms for Long-Term Controlled Release of Therapeutic Proteins and Vaccines" Materials Vol. 9 Iss. 5 (2016) p. 321-1 - 321-13
Available at: http://works.bepress.com/nastaran_hashemi/25/