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Article
Effect of a rotating frame on preventing bead aggregation in a microfluidic device
Advances in Bioscience and Biotechnology
  • Jie Yang, Iowa State University
  • Peter B. Howell, Naval Research Laboratory
  • Nicole N. Hashemi, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
9-1-2012
DOI
10.4236/abb.2012.35078
Abstract
Varying bead concentrations over the course of experiments have been reported by many scientists. A new device was designed and fabricated to eliminate bead aggregation in a syringe pump prior to flowing through a microchannel. We have molded the effects of rotation in the absence of longitudinal flow by evenly populating the cross section of a syringe with particles, then tracking their movement due to rotation, gravity, and centripetal forces. We have shown both experimentally and numerically that the concentration of the beads remains constant over the course of experiments once the rotational device is used. However, the concentration of the beads drops significantly once no rotation is applied during the experiment.
Comments

This article is from Advances in Bioscience and Biotechnology 3 (2012): 603, doi:10.4236/abb.2012.35078. Posted with permission.

Rights
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright Owner
SciRes
Language
en
File Format
application/pdf
Citation Information
Jie Yang, Peter B. Howell and Nicole N. Hashemi. "Effect of a rotating frame on preventing bead aggregation in a microfluidic device" Advances in Bioscience and Biotechnology Vol. 3 Iss. 5 (2012) p. 603 - 608
Available at: http://works.bepress.com/nastaran_hashemi/2/