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Oculomotor Neurocircuitry, a Structural Connectivity Study of Infantile Nystagmus Syndrome
PLOS ONE
  • Nasser H. Kashou, Wright State University - Main Campus
  • Angelica R. Zampini
Document Type
Article
Publication Date
4-10-2015
Abstract
Infantile Nystagmus Syndrome (INS) is one of the leading causes of significant vision loss in children and affects about 1 in 1000 to 6000 births. In the present study, we are the first to investigate the structural pathways of patients and controls using diffusion tensor imaging (DTI). Specifically, three female INS patients from the same family were scanned, two sisters and a mother. Six regions of interest (ROIs) were created manually to analyze the number of tracks. Additionally, three ROI masks were analyzed using TBSS (Tract-Based Spatial Statistics). The number of fiber tracks was reduced in INS subjects, compared to normal subjects, by 15.9%, 13.9%, 9.2%, 18.6%, 5.3%, and 2.5% for the pons, cerebellum (right and left), brainstem, cerebrum, and thalamus. Furthermore, TBSS results indicated that the fractional anisotropy (FA) values for the patients were lower in the superior ventral aspects of the pons of the brainstem than in those of the controls. We have identified some brain regions that may be actively involved in INS. These novel findings would be beneficial to the neuroimaging clinical and research community as they will give them new direction in further pursuing neurological studies related to oculomotor function and provide a rational approach to studying INS.
Comments

© 2015 Kashou, Zampini. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Citation Information
Nasser H. Kashou and Angelica R. Zampini. "Oculomotor Neurocircuitry, a Structural Connectivity Study of Infantile Nystagmus Syndrome" PLOS ONE Vol. 10 Iss. 4 (2015) ISSN: 19326203
Available at: http://works.bepress.com/nasser_kashou/29/