Article
Food dependence in rats selectively bred for low versus high saccharin intake: Implications for “food addiction.”
Appetite
(2011)
Abstract
The "food addiction" concept implies that proneness to drug dependence and to food dependence should covary. The latter was studied in low- (LoS) and high- (HiS) saccharin-consuming rats, who differ in drug self-administration (HiS>LoS) and withdrawal (LoS>HiS). Sugary food intake in the first 1-2 h was higher in HiS than LoS rats. Sugar intake predicted startle during abstinence only among LoS rats. These results may suggest bingeing-proneness in HiS rats and withdrawal-proneness among LoS rats. However, intake escalation and somatic withdrawal did not differ between lines. Further study with selectively bred rats, with attention to definitions and measures, is warranted.
Keywords
- Sugar,
- Startle,
- Dependence,
- Withdrawal,
- Saccharin phenotype
Disciplines
Publication Date
2011
Citation Information
V. Yakovenko, E. R. Speidel, C. D. Chapman and Nancy K Dess. "Food dependence in rats selectively bred for low versus high saccharin intake: Implications for “food addiction.”" Appetite Vol. 57 Iss. 2 (2011) Available at: http://works.bepress.com/nancy_dess/10/