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Replication of Diabetogenic and Nondiabetogenic Variants of Encephalomyocarditis (EMC) Virus in ICR Swiss Mice
Proceedings of the Society for Experimental Biology and Medicine
  • Cheryl L. Gould
  • Mary L. Trombley
  • Nancy J. Bigley, Wright State University - Main Campus
  • Karyle G. McMannama
  • David J. Giron
Document Type
Conference Proceeding
Publication Date
4-1-1984
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Abstract
The replication of the diabetogenic D (EMC-D) and nondiabetogenic B (EMC-B) variants of encephalomyocarditis virus in various tissues of the murine host was determined. Pancreatic insulin levels were also measured. EMC-D replicated in the spleen, pancreas, heart, lung, and intestines, while EMC-B was limited to the spleen and pancreas. EMC-B interfered with the replication of EMC-D in each of the tissues examined. Insulin levels were initially increased by both viruses. By 4 days postinfection, insulin levels were either normal or undetectable in (EMC-D)-infected animals, but were dramatically elevated in those infected with EMC-B.
Citation Information
Cheryl L. Gould, Mary L. Trombley, Nancy J. Bigley, Karyle G. McMannama, et al.. "Replication of Diabetogenic and Nondiabetogenic Variants of Encephalomyocarditis (EMC) Virus in ICR Swiss Mice" Proceedings of the Society for Experimental Biology and Medicine Vol. 175 Iss. 4 (1984) p. 449 - 453 ISSN: 0037-9727
Available at: http://works.bepress.com/nancy_bigley/73/