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CD1d-Reactive T-Cell Activation Leads to Amelioration of Disease Caused by Diabetogenic Encephalomyocarditis Virus
Journal of Leukocyte Biology
  • Mark A. Exley
  • Nancy J. Bigley, Wright State University - Main Campus
  • Olivia Cheng
  • Syed Muhammad Ali Tahir
  • Stephen T. Smiley
  • Quincy L. Carter
  • Harold F. Stills, Jr.
  • Michael J. Grusby
  • Yasuhiko Koezuka
  • Masuru Taniguchi
  • Steven P. Balk
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A subset of CD161 (NK1) T cells express an invariant Vα14Jα281TCR-α chain (Vαinvt T cells) and produce Th2 and Th1cytokines rapidly in response to CD1d, but their physiological function(s) remain unclear. We have found that CD1d-reactive T cells mediate to resistance against the acute, cytopathic virus diabetogenic encephalomyocarditis virus (EMCV-D) in relatively Th1-biased,C57BL/6-based backgrounds. We show now that these results generalize toTh2-biased, hypersensitive BALB/c mice. CD1d-KO BALB/c mice were more susceptible to EMCV-D. Furthermore, α-galactosylceramide(α-GalCer), a CD1d-presented lipid antigen that specifically activates Vαinvt T cells, protected wild-type (WT) mice against EMCV-D-induced encephalitis, myocarditis, and diabetes. In contrast, neither CD1d-KO nor Jα281-KO mice were protected byα-GalCer. Finally, disease in Jα281-KO mice was comparable to WT,indicating for the first time equivalent roles for CD1d-reactiveVαinvt and noninvariant T cells in resistance to acute viral infection. A model for how CD1d-reactive T cells can initiate immune responses, which synthesizes current results, is presented.

A correction to this article (errata) appears in Journal of Leukocyte Biology, 70(2), p. 340, August 2001.

Citation Information
Mark A. Exley, Nancy J. Bigley, Olivia Cheng, Syed Muhammad Ali Tahir, et al.. "CD1d-Reactive T-Cell Activation Leads to Amelioration of Disease Caused by Diabetogenic Encephalomyocarditis Virus" Journal of Leukocyte Biology Vol. 69 Iss. 5 (2001) p. 713 - 718 ISSN: 0741-5400
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