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Article
Specific Inhibition of RH0(D) Antibody by Sialic Acids
Science
  • Matthew C. Dodd
  • Nancy J. Bigley, Wright State University - Main Campus
  • Virginia B. Geyer
Document Type
Article
Publication Date
11-11-1960
Abstract

Agglutination of RhO(D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. A brain ganglioside containing neuraminic acid and a Pseudomonas polysaccharide were even more inhibitory. Inhibition was specific for anti-D sera.

DOI
10.1126/science.132.3437.1398
Citation Information
Matthew C. Dodd, Nancy J. Bigley and Virginia B. Geyer. "Specific Inhibition of RH0(D) Antibody by Sialic Acids" Science Vol. 132 Iss. 3437 (1960) p. 1398 - 1399 ISSN: 0036-8075
Available at: http://works.bepress.com/nancy_bigley/25/