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Article
Autoimmune Response in Rabbits Injected with Rat and Rabbit Liver Ribosomes
Science
  • Matthew C. Dodd
  • Nancy J. Bigley, Wright State University - Main Campus
  • Virginia B. Geyer
  • Francis W. McCoy
  • Henry E. Wilson
Document Type
Article
Publication Date
8-31-1962
Abstract

Autoimmune hemolytic anemia and leukopenia, circulating autoantibodies for erythrocytes, leukocytes, and ribosomes; pathological changes in liver, spleen, heart, brain, and kidneys were produced in rabbits injected with rat or rabbit liver ribosomes. The hematologic and pathologic changes were reproduced by injection of anti-ribosomal serum into normal rabbits. The autoantibody specificity was related primarily to nucleotides and nucleosides.

DOI
10.1126/science.137.3531.688
Citation Information
Matthew C. Dodd, Nancy J. Bigley, Virginia B. Geyer, Francis W. McCoy, et al.. "Autoimmune Response in Rabbits Injected with Rat and Rabbit Liver Ribosomes" Science Vol. 137 Iss. 3531 (1962) p. 688 - 689 ISSN: 0036-8075
Available at: http://works.bepress.com/nancy_bigley/21/