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Article
Murine Response to DNA Encoding Herpes Simplex Virus Type-1 Glycoprotein D Targeted to the Liver
Vaccine
  • James V. Rogers, Wright State University - Main Campus
  • Barbara E. Hull, Wright State University - Main Campus
  • P. S. Fink
  • H. C. Chiou
  • Nancy J. Bigley, Wright State University - Main Campus
Document Type
Article
Publication Date
2-14-2000
Abstract

Plasmid DNA encoding herpes simplex virus type-1 glycoprotein D (gD-1) was complexed with asialoorosomucoid conjugated to poly-L-lysine. Following its intravenous injection into BALB/c mice, this complex was targeted to the liver. Liver cells expressing gD-1 were detected immunohistochemically through day 6 post-immunization, while gD-1 DNA was detectable through 14 days post-immunization. Decline of gD-1 expression and detectable gD-1 DNA in the liver correlated with influx of T cells, predominantly CD4(+). The ASOR-poly-L-lysine DNA carrier system promotes hepatic expression of gD-1 and may be useful in vaccination against herpes simplex virus type-1.

DOI
10.1016/S0264-410X(99)00438-7
Citation Information
James V. Rogers, Barbara E. Hull, P. S. Fink, H. C. Chiou, et al.. "Murine Response to DNA Encoding Herpes Simplex Virus Type-1 Glycoprotein D Targeted to the Liver" Vaccine Vol. 18 Iss. 15 (2000) p. 1522 - 1530 ISSN: 0264-410X
Available at: http://works.bepress.com/nancy_bigley/11/