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About Nancy J. Bigley

The overall objective of my research is to understand the interactions between virus and the host defense system occurring between the first 12 to 24 hours of infection (innate immunity) which leads to susceptibility or resistance to disease (acquisition of adaptive immunity). Previously, the research projects under this objective dealt with: a gender-based difference to the pathogenesis of a picornavirus [the D variant of emcephalomyocarditis virus  {EMCV-D] and a DNA vaccine for herpes simplex virus, type 1 (HSV-1). My ongoing research involves HSV-1, cytokine signaling pathways, SOCS1/SOCS3 in inflammatory/anti-inflammatory cytokine pathways and cytoskeletal changes in macrophages polarized to the M1 and M2 phenotypes.

Positions

Present Professor, Wright State University Neuroscience, Cell Biology & Physiology
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Contact Information

063B Medical Sciences Building
(937) 775-2824

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Articles (53)