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Article
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
Nature Neuroscience
  • Junyu Xu
  • Nan (Tori) Xiao, University of the Pacific
  • Jun Xia
Document Type
Article
DOI
10.1038/nn.2459
Publication Date
1-1-2010
Disciplines
Abstract

In cultured rat hippocampal neurons, we found that thrombospondin 1 (TSP1) increased the speed of synapse formation in young neurons, but not the final density of synapses in mature neurons. TSP1 interacted with neuroligin 1 (NL1) and application of the NL1 extracellular domain blocked TSP1-induced synaptogenesis. Furthermore, knocking down endogenous NL1 inhibited TSP1's effect. Our results indicate that TSP1 accelerates the speed of synaptogenesis through NL1 in hippocampal neurons.

Citation Information
Junyu Xu, Nan (Tori) Xiao and Jun Xia. "Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1" Nature Neuroscience Vol. 13 Iss. 1 (2010) p. 22 - 24 ISSN: 1546-1726
Available at: http://works.bepress.com/nan-xiao/33/