Thesis
Matevosyan NR. Clinical-hormonal Parallels of Pregnancy and Postpartum in Women with Uterine Fibromyomata
(1999)
Abstract
A cohort of 424 pregnant and puerperal women with uterine fibroids (clinical group) and a cohort of 80 pregnant and puerperal women without fibroids (control group) were screened by clinical observations, Radio-Immune analysis (RIA) of six hormones (prolactin, cortisol, testosterone, oestradiol- E2, FSH, LH), fetal CTG, biophysical profile, colpocytography, ultrasound, clotting profile, liver battery, uterine rheography, uterine artery Doppler, placental histology, neonatal screening, breastfeeding and others. Numerical variables (lab results, clinical parametric measures) were entered into the Pearson queue for the association (correlation) analysis. Categorical variables were processed via linear and non-linear regression analyses. Pregnancy and postpartum adverse outcomes in women with uterine fibroids are determined not only by the size, type and location of myomatous nodules, but also by the parity and age of women. The type and size of fibroids is in substantial association (r, 0.857) with parity. Critical periods of pregnancy with fibroids are the 14th, 16th, 28th, 32nd and 34th gestation weeks confirmed by the clotting cascade, rheography of the uterus, sonography of fibroids and their distance from the placenta. At one-year postpartum, the ultrasound reveals growth (19.5%), absence of growth (29.3%), and involution (51.2%) of fibroid nodules. This growth dynamics relates to the type, size of fibroids, and length of exclusive breastfeeding. Postpartum involution is more typical for women with subserous fibroids, and correlates to parity.
Disciplines
Publication Date
Fall October 29, 1999
Degree
PhD (med)
Field of study
Obstetrics and Gynecology, Perinatal Medicine
Citation Information
Naira R. Matevosyan. "Matevosyan NR. Clinical-hormonal Parallels of Pregnancy and Postpartum in Women with Uterine Fibromyomata" (1999) Available at: http://works.bepress.com/naira_matevosyan/96/
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