Article
Matevosyan NR. Zika Virus and Perinatal Outcomes: Beyond the Myth
Critical Care Obstetrics and Gynecology
(2016)
Abstract
The World Health Organization defines the recent outbreak of Zika infection as a Public Health Emergency of International Concern (PHEIC). An attempt was made to contribute to a comprehensive screening protocol for Zika in pregnancy, based on systematic assessment of the empirical data. A total of 34 published articles, randomly located in the major scholarship portals and conferring to the level I-IIA evidence, are sampled to inform clinical, serology, imaging, and histology findings from 8,389 singleton pregnancies. Results of a comparative analysis between Zika-positive and Zika-negative pregnant women presented with macopapular rash suggest that active Zika virus infection is predictive to the adverse perinatal outcomes: prematurity, fetal growth restriction, microcephaly, and Guillain-Barré syndrome. Temporal analysis between the viral peak lags, the first acute rash in women, and perinatal outcomes, support such associations.
Keywords
- Zika virus,
- flavivirus,
- microcephaly,
- Guillain-Barré syndrome,
- white brain damage
Disciplines
Publication Date
Summer July, 2016
DOI
10.21767/2471-9803.100026
Citation Information
Naira R. Matevosyan. "Matevosyan NR. Zika Virus and Perinatal Outcomes: Beyond the Myth" Critical Care Obstetrics and Gynecology Vol. 2 Iss. 4 (2016) Available at: http://works.bepress.com/naira_matevosyan/83/