Article
Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines
Molecular Diversity
Document Type
Article
Publication Date
1-1-2021
Abstract
We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to be effective and tolerant for the amide bond formation reaction of a series of electronically deactivating and sterically challenging amines. The antioxidant potential of the newly synthesized compounds has been evaluated at the later stage. Graphic abstract: [Figure not available: see fulltext.]
DOI Link
10.1007/s11030-021-10275-7
Disciplines
Keywords
- Amide,
- Antioxidant,
- Oxadiazole,
- Synthesis
Scopus ID
85110946625
Indexed in Scopus
Yes
Open Access
No
https://doi.org/10.1007/s11030-021-10275-7
Citation Information
Merla Arjuna Rajendra, Muhammad Naseem, Muthipeedika Nibin Joy, K. Sunil, et al.. "Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines" Molecular Diversity (2021) ISSN: <a href="https://v2.sherpa.ac.uk/id/publication/issn/1381-1991" target="_blank">1381-1991</a> Available at: http://works.bepress.com/muhammad-naseem/13/