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Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
British Journal of Nutrition
  • Kaye E. Brock, University of Sydney
  • Wen-Yi Huang, National Cancer Institute
  • David R. Fraser, University of Sydney
  • Liang Ke, University of Sydney
  • Marilyn Tseng, California Polytechnic State University, San Luis Obispo
  • Rebecca S. Mason, University of Sydney
  • Rachael Z. Stolzenberg-Solomon, National Cancer Institute
  • D. Michal Freedman, National Cancer Institute
  • Jiyoung Ahn, NYU School of Medicine
  • Ulrike Peters, Fred Hutchinson Cancer Research Center in Seattle
  • Catherine McCarty, Marshfield Clinic Research Foundation
  • Bruce W. Hollis, Medical University of South Carolina
  • Regina G. Ziegler, National Cancer Institute
  • Mark P. Purdue, National Cancer Institute
  • Barry I. Graubard, National Cancer Institute
Publication Date
8-1-2011
Abstract
Hypovitaminosis D may be associated with diabetes, hypertension and CHD. However, because studies examining the associations of all three chronic conditions with circulating 25-hydroxyvitamin D (25(0H)D) and 1,25-dihydroxyvitamin D (1,25(0H)2D) are limited, we examined these associations in the US Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (n 2465). Caucasian PLCO participants selected as controls in previous nested case-control studies of 25(0H)D and 1,25(0H)2D were included in this analysis. Diabetes, CHD and hypertension prevalence, risk factors for these conditions and intake of vitamin D and Ca were collected from a baseline questionnaire. Results indicated that serum levels of 25(0H)D were low (<50nmol/1) in 29% and very low ( < 37nmol/1) in 11% of subjects. The prevalence of diabetes, hypertension and CHD was 7, 30 and 10%, respectively. After adjustment for confounding by sex, geographical location, educational level, smoking history, BMI, physical activity, total dietary energy and vitamin D and Ca intake, only diabetes was significantly associated with lower 25(0H)D and 1,25(0H)2D levels. Caucasians who had 25(0H)D 2:80nmol/1 were half as likely to have diabetes (OR 0·5 (95% Cl 0·3, 0·9)) compared with those who had 25(0H)D /l. Those in the highest quartile of 1,25(0H)2D (/1) were less than half as likely to have diabetes (OR 0·3 (95% Cl 0·1, 0·7)) than those in the lowest quartile (< 72pmol/l). In conclusion, the independent associations of 25(0H)D and 1,25(0H)2D with diabetes prevalence in a large population are new findings, and thus warrant confirmation in larger, prospective studies.
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Citation Information
Kaye E. Brock, Wen-Yi Huang, David R. Fraser, Liang Ke, et al.. "Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial" British Journal of Nutrition Vol. 106 Iss. 3 (2011) p. 339 - 344
Available at: http://works.bepress.com/mtseng/31/