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About Michael Pollastri

The primary research focus of our lab is on discovery of new therapeutics for neglected tropical diseases, using a "parachute" or "repurposing" approach. In this approach, we identify parasitic targets of importance that have been previously biochemically validated, with a further focus on those targets with human homologs that have been pursued in human drug discovery. We then prepare known ligands previously reported against the human homolog for assessment against the parasite target, and then pursue an optimization program from that starting point. Our first project is focused on trypanosomal phosphodiesterases, enzymes that have ~30% homology to human PDE4 and 5. Other projects focus on trypansomal TOR, Aurora kinases, dihydrofolate reductase, and HDACs. Our secondary area of focus is on chemical technologies. Projects in this category include diversification of lead compounds using reaction screening approaches, applications of flow chemistry, and Green Chemistry.


Present Associate Professor, Department of Chemistry and Chemical Biology, Northeastern University

Research Interests

Medicinal chemistry and Chemical technology

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Contact Information

417 Egan Research Center
Northeastern University
360 Huntington Ave.
Boston, MA 02115


Articles (6)