Information Technology (IT) has experienced a worrisome decline in female participation over two decades, much of which can be attributed to fewer women choosing IT careers. However, women IT professionals also demonstrate mid-career turnover for reasons such as work-life balance, work exhaustion, role ambiguity, role conflict, and growth needs. This study explores alienation among women IT professionals and examines factors that lead to work alienation and abandonment of IT careers. Such alienation appears to be less prevalent in Asian countries where women perceive IT careers to be more conducive to female participation. A comparison among women from American and Asian cultures is proposed.