Evolutionary theory and neuroscience are recommended as a foundational theory for social work. Advantages of evolutionary theory include explanatory power, suggestion of interventions to beginning social work practitioners, and accommodation of more specific theories of human behavior. The explanatory power of neuroscience is also discussed, along with its evidence base and compatibility with the strengths perspective and destigmatization work of the profession. Connections between evolutionary theory, neuroscience, and social work values are also discussed.