Edge computing has garnered significant attention in recent years, as it enables the extension of cloud resources to the network edge. This enables the user to utilize virtually enhanced resources in terms of storage and computation at a lower cost. The edge computing-assisted wireless wearable communication (EWWC) technology is a prime candidate for e-Health edge applications to collect personal health information (PHI), which leads to disease learning and prediction. Ensuring privacy and efficiency of such system in EWWC is extremely important. In this article, we introduce an efficient and privacypreserving disease prediction scheme. We use the randomizable signature and matrices encryption technique to achieve identity protection and data privacy. The experimental analysis shows that our solution outperforms the existing solution in terms of computational costs and communication overhead. At the same time is able to provide data privacy, prediction model security, user identity protection, mendacious data traceability, and model verifiability. We also analyze potential future research directions related to this emerging area. IEEE