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About Mohan Gupta, Jr.

Dr. Mohan ‘Moe’ Gupta received his B.S degree and Ph.D. in biochemistry from the University of Kansas in Lawrence, KS (2001).  After training as a postdoctoral fellow at the Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts, he served on the faculty of the Department of Molecular Genetics and Cell Biology at the University of Chicago in Chicago, IL. In August 2015 Dr. Gupta joined the Department of Genetics, Development and Cell Biology as a tenure-eligible assistant professor. Microtubules are cytoskeletal filaments of polymerized tubulin protein that are required for many cellular processes including cell division, cell migration, and nervous system development. A critical feature of microtubules, which enables such diverse activities, is that the assembly and disassembly of individual microtubules can be differentially controlled in both space and time within the same cell. The importance of regulating microtubule dynamics is highlighted by two significant impacts on human health – mutations in tubulin result in human neurological disorders and inhibiting microtubule dynamics is a proven anti-cancer therapy. Our research group is focused on determining the mechanisms that control microtubule dynamics in healthy cells, and using our expertise in tubulin biochemistry to understand how defects in microtubule dynamics cause neurological disease and can be leveraged for improved cancer treatments. We design complimentary experiments in live cells and with purified components by exploiting interdisciplinary approaches including cell biology, biochemistry, genetics, biophysics, and multi-color live cell and single molecule microscopy.

Positions

Present Assistant Professor, Iowa State University Department of Genetics, Development and Cell Biology
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Contact Information

457 Bessey
2200 Osborn Dr
Ames, IA 50011
515-294-3951

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Peer-Reviewed Articles (14)

Conference Proceedings (1)