|Present||Assistant Professor, Iowa State University ‐ Department of Genetics, Development and Cell Biology|
2200 Osborn Dr
Ames, IA 50011
Peer-Reviewed Articles (14)
Phenotypic spectrum of the Tubulin-related Disorders and Functional Implications of ...
Current Opinion in Genetics & Development (2011)
A spectrum of neurological disorders characterized by abnormal neuronal migration,differentiation, and axon guidance and maintenance have recently been attributed to ...
Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome
The Journal of Clinical Investigation (2008)
Deficiencies in the SBDS gene result in Shwachman-Diamond syndrome (SDS), an inherited bone marrow failure syndrome associated with leukemia predisposition. SBDS encodes a highly ...
Paclitaxel-induced microtubule stabilization causes mitotic block and apoptotic-like cell death ...
Wild-type Saccharomyces cerevisiae tubulin does not bind the anti-mitotic microtubule stabilizingagent paclitaxel. Previously, we introduced mutations into the S. cerevisiae ...
Conference Proceedings (1)
Understanding tubulin–Taxol interactions: Mutations that impart Taxol binding to ...
Proceedings of the National Academy of Sciences of the United States of America (2003)
We have successfully used mutagenesis to engineer Taxol (paclitaxel) binding activity in Saccharomyces cerevisiae tubulin. Taxol, a successful antitumor agent, acts by ...