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Selected Works of Mohammed Ali
Article
Electrostatic Charge Polarity Effect on Respiratory Deposition in the Glass Bead Tracheobronchial Airways Model
Journal of Arkansas Academy of Science (2007)
  • Mohammed Ali, University of Texas at Tyler
  • Malay K Mazumder, University of Arkansas at Little Rock
  • Rama N. Reddy, University of Arkansas at Little Rock
  • Mariofanna G. Milanova, University of Arkansas at Little Rock
  • Jing Zhang, University of Arkansas at Little Rock
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Abstract
The effects of unipolar and bipolar electrostatic charges on the deposition efficiency of therapeutic aerosols in the physical model of human tracheobronchial (TB) airways have been investigated. Respirable size aerosol particles were generated by a commonly prescribed and commercially available nebulizer and charged by a corona charger and then their size and charge distributions were characterized by an Electronic Single Particle Aerodynamic Relaxation Time analyzer to study the drug aerosol particles' deposition pattern. The experiments were performed with a glass bead tracheobronchial model (GBTBM) (physical model) which was designed and developed based upon widely used and adopted dichotomous lung morphometric data presented in the Ewald R. Weibel model. The model was validated with the respiratory deposition data predicted by the International Commission on Radiological Protection and the United States Pharmacopeia (USP) approved Andersen Cascade Impactor (ACI). Unipolarly and bipolarly charged particles were characterized for two configurations: a) without TB model in place and b) with TB model in place. Findings showed that the deposition of unipolarly charged particles was about 3 times of the bipolarly charged particles. It was also found that bioengineered therapeutic aerosols with good combinations of aerodynamic size and electrostatic charge are good candidates for the administration of respiratory medicinal drugs.
Keywords
  • Electrostatic Charge Polarity Effect,
  • Respiratory Deposition,
  • Tracheobronchial Airways Model
Disciplines
Publication Date
2007
Citation Information
Mohammed Ali, Malay K Mazumder, Rama N. Reddy, Mariofanna G. Milanova, et al.. "Electrostatic Charge Polarity Effect on Respiratory Deposition in the Glass Bead Tracheobronchial Airways Model" Journal of Arkansas Academy of Science Vol. 61 Iss. 1 (2007) p. 20 - 26 ISSN: 2326-0505
Available at: http://works.bepress.com/mohammedali/18/