In 2011, 4,432 pedestrians were killed (14% of total traffic crash fatalities), and 69,000 pedestrians were injured in vehicle-pedestrian crashes in the United States. Particularly in Louisiana, vehicle-pedestrian crashes have become a key concern because of the high percentage of fatalities in recent years. In 2012, pedestrians were accounted for 17% of all fatalities due to traffic crashes in Louisiana. Alcohol was involved in nearly 44% of these fatalities. This research utilized ‘a priori’ algorithm of supervised association mining technique to discover patterns from the vehicle-pedestrian crash database. By using association rules mining, this study aims to discover vehicle-pedestrian crash patterns using eight years of Louisiana crash data (2004–2011). The results indicated that roadway lighting at night helped in alleviating pedestrian crash severity. In addition, a few groups of interest were identified from this study: male pedestrians’ greater propensity towards severe and fatal crashes, younger female drivers (15–24) being more crash-prone than other age groups, vulnerable impaired pedestrians even on roadways with lighting at night, middle-aged male pedestrians (35–54) being inclined towards crash occurrence, and dominance of single vehicle crashes. Based on the recognized patterns, this study recommends several countermeasures to alleviate the safety concerns. The findings of this study will help traffic safety professionals in understanding significant patterns and relevant countermeasures to raise awareness and improvements for the potential decrease of pedestrian crashes.