Skip to main content
Assesment of Alterations in the Electrical Impedance of Muscle after Experimental Nerve Injury via Finite Element Analysis
IEEE Transaction of Biomedical Engineering (2011)
  • Mohammad A. Ahad, Havard Medical School
  • Lucy L. Wang, Harvard Medical School
  • Alistair McEwan, University of Sydney
  • Jia Li, Harvard Medical School
  • Mina Jafarpoor, Harvard Medical School
  • Seward B. Rutkove, Harvard Medical School
The surface measurement of electrical impedance of muscle, incorporated as the technique of electrical impedance myography (EIM), provides a noninvasive approach for evaluating neuromuscular diseases, including amyotrophic lateral sclerosis. However, the relationship between alterations in surface impedance and the electrical properties of muscle remains uncertain. In order to investigate this further, a group of healthy adult rats, a group of rats two weeks postsciatic crush, and a group of animals six months postcrush underwent EIM of the gastrocnemius–soleus complex. The animals were then killed and the conductivity and permittivity of the extracted muscle measured. Finite-element models based on MRI data were then constructed for each group. The characteristic EIM parameter, 50 kHz phase (±standard error), obtained with surface impedance measurements was 17.3◦ ± 0.3◦ for normal animals, 13.8◦ ± 0.7◦ for acutely injured animals, and 16.1◦ ± 0.5◦ for chronically injured animals. The models predicted parallel changes with phase values of 24.3◦, 18.8◦, and 21.2◦ for the normal, acute, and chronic groups, respectively. Other multifrequency impedance parameters showed similar alterations. These results confirm that surface impedance measurements taken in conjunction with anatomical data and finite-element models may offer a noninvasive approach for assessing biophysical alterations in muscle in neuromuscular disease states.
  • Element methods,
  • Impedance,
  • Muscle
Publication Date
June, 2011
Citation Information
Mohammad A. Ahad, Lucy L. Wang, Alistair McEwan, Jia Li, et al.. "Assesment of Alterations in the Electrical Impedance of Muscle after Experimental Nerve Injury via Finite Element Analysis" IEEE Transaction of Biomedical Engineering Vol. 58 Iss. 6 (2011) p. 1585 - 91
Available at: