Accidental Collisions Involving Over-Height Trucks That Exceed Vertical Clearance Limits And Bridge Superstructures Frequently Happen, Resulting In Compromised Girders And Potential Threats To Structural Safety And Performance. The Numerical Simulation Of Large-Scale Prestressed Girder Bridge Collisions Poses Challenges Due To The Associated Nonlinearities, As Well As The Limited Availability Of Large-Scale Experimental Testing Data In The Literature Due To Cost And Complexity Constraints. This Study Introduces A Numerical Modeling Approach To Efficiently Capture The Response Of Prestressed Girder Bridges Under Lateral Impact Loads. A Finite Element (FE) Model Was Developed Using LS-DYNA And Meticulously Validated Against Experimental Data From The Literature. The Study Explored Four Methods For Applying Prestressing Forces And Evaluated The Performance Of Four Concrete Material Constitutive Models, Including The Continuous Surface Cap Model (CSCM), Concrete Damage Plastic Model (CDPM), Karagozian & Case Concrete (KCC) Model, And Winfrith Concrete Model, Under Impact Loads. Furthermore, An Impact Study Was Conducted To Investigate The Influence Of Impact Speed, Impact Mass, And Prestressing Force On The Behavior Of Prestressed Girder Bridges. Utilizing The Dynamic Relaxation (DR) Approach, The Developed FE Model Precisely Captured The Response Of Prestressed Girders Under Impact Loads. The CSCM Yielded The Most Accurate Predictions Of Impact Forces, With An Error Of Less Than 8%, And Demonstrated A Strong Ability To Predict Damage Patterns. Impact Speed, Mass, And The Presence Of Prestressing Force Showed A Significant Influence On The Resulting Peak Impact Force Experienced By The Girder. Furthermore, The Study Underscores The Composite Nature Of The Bridge's Response And Emphasizes The Importance Of Analyzing The Bridge As A Whole Rather Than Focusing Solely On Individual Girders.