This case study provides an overview of environmental and health issues regarding the transboundary trade of hazardous substances such as various chemical waste, including pesticides, which can affect human condition and the environment, especially in developing countries. Primary discussions have risen to address these concerns, and to design regulations for the proper use and legal trade of these substances. The study also provides an in-depth analysis on the various approaches in a national and international level, to control the impact of these regulations worldwide.