Presentation
Serum leptin, anthropometric phenotypes and epigenetic programming across 7 Leptin (LEP) core promoter CpG sites in two diverse populations: The Western Buryat of Siberia and the Mennonites of Central Kansas
The 85th Annual Meeting of the American Association of Physical Anthropologists
(2016)
Abstract
Current research demonstrates epigenetic influences on early developmental plasticity and phenotypic variation into adulthood. The epigenetic mechanisms provide for a rapid, flexible, and heritable yet potentially reversible adaptive response on DNA sequences. Genes regulating metabolism are vulnerable to nutritional programming over the life course and experience alterations in DNA methylation density. The gene leptin (LEP) involves regulation of energy homeostasis. Synthesized by adipocytes, leptin influences adipogenesis, energy storage, lipid and glucose metabolism, as well as reproductive endocrine function. Variation of DNA methylation in the LEP core promoter correlates with dietary intake; however, phenotypic significance of that variation is unclear. We hypothesize that evidence of epigenetic programming would be identified through differential DNA methylation and biomarkers reflecting leptin’s metabolic signals.
Keywords
- Serum leptin,
- Epigenetic influences
Disciplines
Publication Date
April, 2016
Location
Atlanta, GA
Citation Information
2016 Mosher MJ, Melton PE, Stapleton P, Crawford MH. Serum leptin, anthropometric phenotypes and epigenetic programming across 7 Leptin (LEP) core promoter CpG sites in two diverse populations: The Western Buryat of Siberia and the Mennonites of Central Kansas.
AAPA Conference Atlanta, 2016.