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Selected Works of M.J. Mosher
Article
Genomic evidence for the Pleistocene and recent population history of Native Americans
Science (2015)
  • Maanasa Raghavan, Wild Center
  • Matthias Steinrücken, University of Massachusetts Amherst
  • Matthias Steinrücken, University of California, Berkeley
  • Kelley Harris, University of California, Berkeley
  • Stephan Schiffels, Wellcome Trust Sanger Institute
  • Simon Rasmussen, Technical University of Denmark
  • Michael DeGiorgio, Pennsylvania State University
  • Anders Albrechtsen, University of Copenhagen
  • Cristina Valdiosera, La Trobe University
  • Cristina Valdiosera, Wild Center
  • María C. Ávila-Arcos, Stanford University
  • María C. Ávila-Arcos, Wild Center
  • Anna-Sapfo Malaspinas, Wild Center
  • Anders Eriksson, University of Cambridge
  • Anders Eriksson, King Abdullah University of Science and Technology
  • Ida Moltke, University of Copenhagen
  • Mait Metspalu, Estonian Biocentre
  • Mait Metspalu, University of Tartu
  • Julian R. Homburger, Stanford University
  • Jeff Wall, University of California, San Francisco
  • Omar E. Cornejo, Washington State University
  • J. Víctor Moreno-Mayar, Wild Center
  • Thorfinn S. Korneliussen, Wild Center
  • Tracey Pierre, Wild Center
  • Morten Rasmussen, Stanford University
  • Morten Rasmussen, Wild Center
  • Paula F. Campos, University of Porto
  • Paula F. Campos, Wild Center
  • Peter de Barros Damgaard, Wild Center
  • Morten E. Allentoft, Wild Center
  • John Lindo, University of Illinois at Urbana–Champaign
  • Ene Metspalu, Estonian Biocentre
  • Ene Metspalu, University of Tartu
  • Ricardo Rodríguez-Varela, Instituto de Salud Carlos III
  • Josefina Mansilla
  • Celeste Henrickson, University of Utah
  • Andaine Seguin-Orlando, Wild Center
  • Helena Malmström, Science for Life Laboratory
  • Thomas Stafford, Aarhus University
  • Thomas Stafford, Wild Center
  • Suyash S. Shringarpure, Stanford University
  • Andrés Moreno-Estrada, CINVESTAV
  • Andrés Moreno-Estrada, Stanford University
  • Monika Karmin, Estonian Biocentre
  • Monika Karmin, University of Tartu
  • Kristiina Tambets, Estonian Biocentre
  • Anders Bergström, Wellcome Trust Sanger Institute
  • Yali Xue, Wellcome Trust Sanger Institute
  • Vera Warmuth
Link
Abstract
How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative “Paleoamerican” relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.
Keywords
  • Genomic evidence,
  • Native Americans,
  • Ancestral Native Americans
Disciplines
Publication Date
August 21, 2015
DOI
10.1126/science.aab3884
Publisher Statement
Published by the American Association for the Advancement of Science.
Citation Information
2015 Raghavan M, Steinrücken M, Harris K, Schiffels S, Rasmussen S, DeGiorgio M, Albrechtsen A, Valdiosera C, Ávila-Arcos MC, Malaspinas AS, Eriksson A, Moltke I, Metspalu M, Homburger JR, Wall J, Cornejo OE, J. Moreno-Mayar V, Korneliussen TS, Pierre T, Rasmussen M, Campos PF, Damgaard P, Allentoft ME, Lindo J, Metspalu E, Rodríguez-Varela R, Mansilla J, Henrickson C, Seguin-Orlando A, Malmström H, Stafford T Jr., Shringarpure S, Moreno-Estrada A, Karmin M, Tambets K, Bergström A, Xue Y, Warmuth V, Friend AD, Singarayer J, Valdes P, Balloux F, Leboreiro I, Vera JL, Rangel-Villalobos H, Pettener D, Luiselli D, Davis LG, Heyer E, Zollikofer CPE, Ponce de León MS, Smith CI, Grimes V, Pike KA, Deal M, Fuller BT, Arriaza B, Standen V, Luz MF, Ricaut F, Guidon N, Osipova L, Voevoda MI, Posukh OL, Balanovsky O, Lavryashina M, Bogunov Y, Khusnutdinova E, Gubina M, Balanovska E, Fedorova S, Litvinov S, Malyarchuk B, Derenko M, Mosher MJ, Archer D, Cybulski J, Petzelt B, Mitchell J, Worl R, Norman PJ, Parham P, Kemp BM, Kivisild T, Tyler-Smith C, Sandhu MS, Crawford M, Villems R, Smith DG, Waters MR, Goebel T, Johnson JR, Malhi RS, Jakobsson M, Meltzer DJ, Manica A, Durbin R, Bustamante CD, Song YS, Nielsen R, and Willerslev E. Genomic evidence for the Pleistocene and recent population history of Native Americans. Science [DOI:10.1126/science.aab3884].