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Netrin (UNC-6) mediates dendritic self-avoidance
Nature Neuroscience (2012)
  • C K Smith, Vanderbilt University
  • J D Watson, Vanderbilt University
  • Miri VanHoven, San Jose State University
  • D A Colón-Ramos, Yale University
  • D M Miller, Vanderbilt University
Dendrites from a single neuron may be highly branched but typically do not overlap. Self-avoidance behavior has been shown to depend on cell-specific membrane proteins that trigger mutual repulsion. Here we report the unexpected discovery that a diffusible cue, the axon guidance protein UNC-6 (Netrin), is required for self-avoidance of sister dendrites from the PVD nociceptive neuron in Caenorhabditis elegans. We used time-lapse imaging to show that dendrites fail to withdraw upon mutual contact in the absence of UNC-6 signaling. We propose a model in which the UNC-40 (Deleted in Colorectal Cancer; DCC) receptor captures UNC-6 at the tips of growing dendrites for interaction with UNC-5 on the apposing branch to induce mutual repulsion. UNC-40 also responds to dendritic contact through another pathway that is independent of UNC-6. Our findings offer a new model for how an evolutionarily conserved morphogenic cue and its cognate receptors can pattern a fundamental feature of dendritic architecture.
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Citation Information
C K Smith, J D Watson, Miri VanHoven, D A Colón-Ramos, et al.. "Netrin (UNC-6) mediates dendritic self-avoidance" Nature Neuroscience Vol. 15 (2012)
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