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The Pattern Of β-Catenin-Responsiveness within the Mammary Gland is Regulated by Progesterone Receptor
Development (2007)
  • Minoti Hiremath, Boise State University
  • John Lydon, Baylor College of Medicine
  • Pamela Cowin
Abstract

Experiments involving β-catenin loss- and gain-of-function in the mammary gland have decisively demonstrated the role of this protein in normal alveologenesis. However, the relationship between hormonal and β-catenin signaling has not been investigated. In this study, we demonstrate that activated β-catenin rescues alveologenesis in progesterone receptor (PR; Pgr)-null mice during pregnancy. Two distinct subsets of mammary cells respond to expression of ΔN89β-catenin. Cells at ductal tips are inherently β-catenin-responsive and form alveoli in the absence of PR. However, PR activity confers β-catenin responsiveness to progenitor cells along the lateral ductal borders in the virgin gland. Once activated by β-catenin, responding cells switch on an alveolar differentiation program that is indistinguishable from that observed in pregnancy and is curtailed by PR signaling.

Keywords
  • Beta-catenin,
  • Breast,
  • Progesterone receptor,
  • Mammary gland,
  • Wnt,
  • Mouse,
  • Stem cells
Disciplines
Publication Date
October 1, 2007
Citation Information
Minoti Hiremath, John Lydon and Pamela Cowin. "The Pattern Of β-Catenin-Responsiveness within the Mammary Gland is Regulated by Progesterone Receptor" Development Vol. 134 (2007)
Available at: http://works.bepress.com/minoti_hiremath/1/