Amphetamine Selectively Enhances Avoidance Responding to a Less Salient Stimulus in RatsFaculty Publications, Department of Psychology
Date of this Version1-1-2008
AbstractThis preclinical study examined the psychological processes affected by amphetamine that contribute to human psychosis. Using a novel avoidance conditioning paradigm involving two conditioned stimuli (CS) with varied salience, we found that acute amphetamine (1.5 mg/ kg, i.p.) selectively enhanced avoidance responding to a less salient stimulus, but not to a salient one. These findings suggest that elevated dopaminergic activity selectively enhances the attributions of motivational salience to a less salient stimulus, a process that may bear relevance to the development of human delusional thoughts.
Citation InformationMing Li, Wei He and Rebecca Munro. "Amphetamine Selectively Enhances Avoidance Responding to a Less Salient Stimulus in Rats" (2008)
Available at: http://works.bepress.com/ming_li/13/