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Amphetamine Selectively Enhances Avoidance Responding to a Less Salient Stimulus in Rats
Faculty Publications, Department of Psychology
  • Ming Li, University of Nebraska-Lincoln
  • Wei He, University of Nebraska at Lincoln
  • Rebecca Munro, University of Nebraska at Lincoln
Date of this Version
1-1-2008
Comments
Published in the Journal of Neural Transmission (2008) 115: 773-776. Copyright 2007, Springer Verlag. Used by permission. doi 10.1007/s00702-007-0002-7.
Abstract
This preclinical study examined the psychological processes affected by amphetamine that contribute to human psychosis. Using a novel avoidance conditioning paradigm involving two conditioned stimuli (CS) with varied salience, we found that acute amphetamine (1.5 mg/ kg, i.p.) selectively enhanced avoidance responding to a less salient stimulus, but not to a salient one. These findings suggest that elevated dopaminergic activity selectively enhances the attributions of motivational salience to a less salient stimulus, a process that may bear relevance to the development of human delusional thoughts.
Citation Information
Ming Li, Wei He and Rebecca Munro. "Amphetamine Selectively Enhances Avoidance Responding to a Less Salient Stimulus in Rats" (2008)
Available at: http://works.bepress.com/ming_li/13/