Coral reef preservation is a challenge for the whole of humanity, not just for the estimated three billion people that directly depend upon coral reefs for their livelihoods and food security. Ocean acidification combined with rising sea surface temperatures, and an array of other anthropogenic influences such as pollution, sedimentation, over fishing, and coral mining represent the key threats currently facing coral reef survival. Here we summarize a list of agreements, policies, and socio-economic tools and instruments that can be used by global, national and local decision-makers to address ocean acidification and associated threats, as identified during an expert workshop in October 2017. We then discuss these tools and instruments at a global level and identify the key tasks for raising decision makers’ awareness. Finally, we suggest ways of prioritizing between different actions or tools for mitigation and adaptation.