Behavioral Sensitization to Cocaine: Modulation by the Cyclic AMP System in the Nucleus AccumbensPsychology Faculty Publications
AbstractExamined the involvement of the cyclic adenosine monophosphate (cAMP) system at the level of the nucleus accumbens (NAc) in cocaine-induced locomotor activity and sensitization. 36 male rats were pretreated on 3 consecutive days with cocaine concurrently with intraaccumbens infusion of saline, 8-bromo-cAMP, or RP-CPT-cAMP. Ss and controls were tested for locomotor activity on pretreatment days and following an additional cocaine challenge on a subsequent day. Over pretreatment days, Ss given 8-bromo-cAMP showed greater cocaine-induced activity, while Ss given RP-CPT-cAMP tended to be less active. When subsequently challenged with cocaine, Ss pretreated with 8-bromo-cAMP showed greater locomotor activity. Data suggest that protein kinase activation at the level of the NAc may have a facilitative role with respect to acute and long-term stimulant-induced locomotor activity.
Citation InformationMiserendino, Mindy, Nestler, Eric J. "Behavioral Sensitization to Cocaine: Modulation by the Cyclic AMP System in the Nucleus Accumbens." Brain Research 674.2 (1995) 299-306.