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Article
Axial level-specific regulation of neuronal development: Lessons from PITX2
Journal of Neuroscience Research (2015)
  • Mindy Waite, PhD, Aurora Research Institute
Abstract
Transcriptional regulation of gene expression is vital for proper control of proliferation, migration, differentiation, and survival of developing neurons. Pitx2 encodes a homeodomain transcription factor that is highly expressed in the developing and adult mammalian brain. In humans, mutations in PITX2 result in Rieger syndrome, characterized by defects in the development of the eyes, umbilicus, and teeth and variable abnormalities in the brain, including hydrocephalus and cerebellar hypoplasia. Alternative splicing of Pitx2 in the mouse results in three isoforms, Pitx2a, Pitx2b, and Pitx2c, each of which is expressed symmetrically along the left–right axis of the brain throughout development. Here, we review recent evidence for axial and brain region-specific requirements for Pitx2 during neuronal migration and differentiation, highlighting known isoform contributions.
Keywords
  • brain,
  • migration,
  • differentiation,
  • spinal cord
Publication Date
February, 2015
DOI
10.1002/jnr.23471
Citation Information
Mindy Waite. "Axial level-specific regulation of neuronal development: Lessons from PITX2" Journal of Neuroscience Research Vol. 93 Iss. 2 (2015) p. 195 - 198
Available at: http://works.bepress.com/mindy-waite/5/