This paper presents a robust longitudinal comparison of student learning in face-to-face (F2F), online, and hybrid delivery methods of a two-course sequence in information systems, required of all business majors, at a Midwestern land grant university. Student learning was evaluated by delivery method in the introductory first class of the sequence, using an ordered probit regression model of letter grade earned controlling for the effects of other possible explanatory variables. Cumulative grade point average was found to be a consistent determinant in student success, and students were found to have significantly better learning outcomes, as expressed through course grades, in the F2F delivery mode for the introductory class. Student grades were then evaluated in the next, more advanced information systems course, using a second ordered probit regression model. The results indicated that mode of delivery, online or F2F, for the more advanced course had no significant impact on student grades for that course, but students who had enrolled in the online and hybrid delivery modes in the first course of the sequence performed significantly better, as measured by course grade, in the more advanced course regardless of delivery mode.