Skip to main content
Article
Predictors of adherence in the Women's Health Initiative Calcium and Vitamin D Trial
Women’s Health Research Faculty Publications
  • Robert L. Brunner, University of Nevada School of Medicine
  • Jacqueline Dunbar-Jacob, University of Pittsburgh School of Nursing
  • Meryl S. LeBoff, Brigham and Women's Hospital
  • I. Granek, Stony Brook University
  • Deborah J. Bowen, Fred Hutchinson Cancer Research Center
  • Linda G. Snetselaar, University of Iowa
  • Sally A. Shumaker, Wake Forest University School of Medicine
  • Judith K. Ockene, University of Massachusetts Medical School
  • Milagros C. Rosal, University of Massachusetts Medical School
  • Jean Wactawski-Wende, State University of New York
  • Jane A. Cauley, University of Pittsburgh
  • Barbara B. Cochrane, Fred Hutchinson Cancer Research Center
  • Lesley F. Tinker, Fred Hutchinson Cancer Research Center
  • Rebecca D. Jackson, The Ohio State University
  • C. Y. Wang, Fred Hutchinson Cancer Research Center
  • L. Wu, Fred Hutchinson Cancer Research Center
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Date
12-1-2009
Document Type
Article
Subjects
Aged; Attitude to Health; Calcium, Dietary; *Dietary Supplements; Double-Blind Method; Female; Forecasting; Humans; Longitudinal Studies; Medication Adherence; Middle Aged; Postmenopause; Risk Factors; Vitamin D; *Women's Health
Abstract
The authors analyzed data from the Women's Health Initiative (WHI) Calcium and Vitamin D Supplementation Trial (CaD) to learn more about factors affecting adherence to clinical trial study pills (both active and placebo). Most participants (36,282 postmenopausal women aged 50-79 years) enrolled in CaD 1 year after joining either a hormone trial or the dietary modification trial of WHI. The WHI researchers measured adherence to study pills by weighing the amount of remaining pills at an annual study visit; adherence was primarily defined as taking > or = 80% of the pills. The authors in this study examined a number of behavioral, demographic, procedural, and treatment variables for association with study pill adherence. They found that relatively simple procedures (ie, phone contact early in the study [4 weeks post randomization] and direct social contact) later in the trial may improve adherence. Also, at baseline, past pill-use experiences, personal supplement use, and relevant symptoms may be predictive of adherence in a supplement trial.
Rights and Permissions
Citation: Behav Med. 2009 Winter;34(4):145-55. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
19064373
Citation Information
Robert L. Brunner, Jacqueline Dunbar-Jacob, Meryl S. LeBoff, I. Granek, et al.. "Predictors of adherence in the Women's Health Initiative Calcium and Vitamin D Trial" Vol. 34 Iss. 4 (2009) ISSN: 0896-4289 (Linking)
Available at: http://works.bepress.com/milagros_rosal/71/