A laser beam propagation model that accounts for the joint effect of atmospheric turbulence and refractivity is introduced and evaluated through numerical simulations. In the numerical analysis of laser beam propagation, refractive index inhomogeneities along the atmospheric propagation path were represented by a combination of the turbulence-induced random fluctuations described in the framework of classical Kolmogorov turbulence theory and large-scale refractive index variations caused by the presence of an inverse temperature layer. The results demonstrate that an inverse temperature layer located in the vicinity of a laser beam’s propagation path may strongly impact the laser beam statistical characteristics including the beam wander and long-exposure beam footprint, and be a reason for refractivity-induced spatial anisotropy of these characteristics.