Article
Synthesis of Kurasoin B Using Phase-Transfer-Catalyzed Acylimidazole Alkylation
Synlett
Document Type
Article
Publication Date
1-1-2009
Publisher
Thieme Publishing
Disciplines
Abstract
The hydroxy ketone natural product kurasoin B is synthesized using a phase-transfer-catalyzed alkylation reaction with benzyloxyacetyl imidazole. A biscinchonidinium dimethylnaphthalene catalyst allowed for high yield and near complete selectivity (99% ee) for the S-product using 3-methylbromoindole as the electrophile.
Citation Information
Christiansen, M. A.; Butler, A. W.; Hill, A. R. Andrus, M. B. “Synthesis of Kurasoin B Using Phase-Transfer-Catalyzed Acylimidazole Alkylation.” Synlett, 2009, 4, 653-657.