Inhibition of Ras-Effector Interaction by Cyclic Peptides.Medical Chemistry Communications (2013)
A combinatorial library of 6 × 106 cyclic peptides was synthesized in the one bead-two compound format, with each bead displaying a unique cyclic peptide on its surface and a linear peptide encoding tag in its interior. Screening of the library against K-Ras identified compounds that bound K-Ras with submicromolar affinity and disrupted its interaction with effector proteins.
Publication DateFebruary 1, 2013
Citation InformationMiguel A. Villalona Calero. "Inhibition of Ras-Effector Interaction by Cyclic Peptides." Medical Chemistry Communications Vol. 4 Iss. 2 (2013) p. 378 - 382
Available at: http://works.bepress.com/miguel-villalonacalero/81/