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Posttransplant lymphoproliferative disorder in pediatric patients: Survival rates according to primary sites of occurrence and a proposed clinical categorization
American Journal of Transplantation (2019)
  • Arnaud G L'Huillier
  • Anne I Dipchand
  • Vicky L Ng
  • Diane Hebert
  • Yaron Avitzur
  • Melinda Solomon
  • Bo-Yee Ngan
  • Derek Stephens
  • Angela S Punnett
  • Michelle Barton-Forbes, Western University
  • Upton D Allen
Abstract
Posttransplant lymphoproliferative disorder (PTLD) is a devastating complication of organ transplant. In a hospital-based registry, we identified biopsy-proven cases of PTLD among children during a 15-year period and reviewed trends in PTLD rates, the sites of involvement, and the associated survival rates. Cases that were included had at least 1 year of follow-up after the diagnosis of PTLD. We studied 82 patients with first-episode PTLD. Median age at diagnosis was 6.4 years (IQR 3.2-12.3 years). The most frequent PTLD sites were tonsillar/adenoidal (T/A [34%]) and gastrointestinal (32%), followed by miscellaneous (defined as less common sites including central nervous system, kidney, lung, and soft tissue [12%]), lymph node (11%), and multisite (11%). Kaplan-Meier survival curves showed that T/A PTLD was associated with decreased all-cause mortality compared with PTLD at other sites (log-rank 0.004), even after adjustment for histological subtype (P = .047). PTLD-related mortality was also decreased among T/A PTLD (log-rank 0.012) but showed a trend toward significance only after adjustment for histological subtype (P = .09). Among first episodes of PTLD, T/A PTLD was associated with a survival advantage compared with PTLD at other sites, even after adjustment for potential confounders. Based on our observations, we propose a clinical categorization of PTLD according to anatomical site of occurrence.

Keywords: Epstein-Barr Virus (EBV); cancer/malignancy/neoplasia; classification systems; clinical research/practice; hematogenous/leukemia/lymphoma; hematology/oncology; infection and infectious agents - viral; infectious disease; patient survival; pediatrics; posttransplant lymphoproliferative disorder (PTLD).
Disciplines
Publication Date
2019
Citation Information
Arnaud G L'Huillier, Anne I Dipchand, Vicky L Ng, Diane Hebert, et al.. "Posttransplant lymphoproliferative disorder in pediatric patients: Survival rates according to primary sites of occurrence and a proposed clinical categorization" American Journal of Transplantation (2019)
Available at: http://works.bepress.com/michelle-barton-forbes/6/