The neurobiology of antiepileptic drugsNature Reviews Neurosci (2004)
AbstractAntiepileptic drugs (AEDs) provide satisfactory control of seizures for most patients with epilepsy. The drugs have the remarkable ability to protect against seizures while permitting normal functioning of the nervous system. AEDs act on diverse molecular targets to selectively modify the excitability of neurons so that seizure-related firing is blocked without disturbing non-epileptic activity. This occurs largely through effects on voltage-gated sodium and calcium channels, or by promoting inhibition mediated by GABA-A (γ-aminobutyric acid, type A) receptors. The subtle biophysical modifications inchannel behaviour that are induced by AEDs are often functionally opposite to defects in channel properties that are caused by mutations associated with epilepsy in humans.
- Antiepileptic drug
Publication DateJuly, 2004
Citation InformationMichael A. Rogawski and Wolfgang Löscher. "The neurobiology of antiepileptic drugs" Nature Reviews Neurosci Vol. 5 Iss. 7 (2004)
Available at: http://works.bepress.com/michael_rogawski/9/