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Article
Pediatric Super-refractory Status Epilepticus Treated with Allopregnanolone
Annals of Neurology (2014)
  • Eileen Broomall, Northwestern University
  • JoAnne E Natale, University of California, Davis
  • Michele Grimason, Northwestern University
  • Joshua Goldstein, Northwestern University
  • Craig M Smith, Northwestern University
  • Celia Chang, University of California, Davis
  • Stephen Kanes
  • Michael A. Rogawski, University of California - Davis
  • Mark S Wainwright, Northwestern University
Abstract
Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic GABA-A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABA-A receptors. Here we describe the use of allopregnanolone in two pediatric patients with super-refractory status epilepticus. This treatment allowed the general anesthetic infusions to be weaned with resolution of status epilepticus. This is the first report of allopregnanolone use to treat status epilepticus in children.
Keywords
  • status epilepticus,
  • seizure,
  • epilepsy,
  • allopregnanolone,
  • neurosteroid
Disciplines
Publication Date
2014
Publisher Statement
Available at: http://dx.doi.org/10.1002/ana.24295
Citation Information
Eileen Broomall, JoAnne E Natale, Michele Grimason, Joshua Goldstein, et al.. "Pediatric Super-refractory Status Epilepticus Treated with Allopregnanolone" Annals of Neurology Vol. 76 Iss. 6 (2014)
Available at: http://works.bepress.com/michael_rogawski/69/