Skip to main content
Contribution to Book
Cellular Effects of Antiepileptic Drugs
Epilepsy: A Comprehensive Textbook (2008)
  • Robert L Macdonald, Vanderbilt University
  • Michael A Rogawski, University of California - Davis
Abstract
Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets, which include various ion channels, a neurotransmitter transporter, a neurotransmitter metabolic enzyme, and a synaptic vesicle protein. AED actions on these targets can be categorized into four broad groups: 1. Modulation of voltage-dependent ion channels (mainly sodium [Na] but also calcium [Ca] channels) 2. Effects on γ-aminobutyric acid (GABA) systems, including alterations in the cellular disposition of GABA and enhancement of synaptic inhibition mediated by GABA-A receptors 3. Inhibition of synaptic excitation mediated by ionotropic glutamate receptors 4. Modulation of neurotransmitter release, particularly of glutamate, through presynaptic mechanisms.
Publication Date
2008
Editor
J. Engel, T.A. Pedley
Publisher
Wolters Kluwer/Lippincott Williams & Wilkins
ISBN
978-0781757775
Citation Information
Robert L Macdonald and Michael A Rogawski. "Cellular Effects of Antiepileptic Drugs" SecondPhiladelpiaEpilepsy: A Comprehensive Textbook Vol. II (2008)
Available at: http://works.bepress.com/michael_rogawski/20/