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Contribution to Book
Cellular Effects of Antiepileptic Drugs
Epilepsy: A Comprehensive Textbook (2008)
  • Robert L Macdonald, Vanderbilt University
  • Michael A Rogawski, University of California - Davis
Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets, which include various ion channels, a neurotransmitter transporter, a neurotransmitter metabolic enzyme, and a synaptic vesicle protein. AED actions on these targets can be categorized into four broad groups: 1. Modulation of voltage-dependent ion channels (mainly sodium [Na] but also calcium [Ca] channels) 2. Effects on γ-aminobutyric acid (GABA) systems, including alterations in the cellular disposition of GABA and enhancement of synaptic inhibition mediated by GABA-A receptors 3. Inhibition of synaptic excitation mediated by ionotropic glutamate receptors 4. Modulation of neurotransmitter release, particularly of glutamate, through presynaptic mechanisms.
Publication Date
J. Engel, T.A. Pedley
Wolters Kluwer/Lippincott Williams & Wilkins
Citation Information
Robert L Macdonald and Michael A Rogawski. "Cellular Effects of Antiepileptic Drugs" SecondPhiladelpiaEpilepsy: A Comprehensive Textbook Vol. II (2008)
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