Do Amino Acid Biosynthetic Costs Constrain Protein Evolution in Saccharomyces cerevisiae?Journal of Molecular Evolution
AbstractProkaryotic organisms preferentially utilize less energetically costly amino acids in highly expressed genes. Studies have shown that the proteome of Saccharomyces cerevisiae also exhibits this behavior, but only in broad terms. This study examines the question of metabolic efficiency as a proteome-shaping force at a finer scale, examining whether trends consistent with cost minimization as an evolutionary force are present independent of protein function and amino acid physicochemical property, and consistently with respect to amino acid biosynthetic costs. Inverse correlations between the average amino acid biosynthetic cost of the protein product and the levels of gene expression in S. cerevisiae are consistent with natural selection to minimize costs. There are, however, patterns of amino acid usage that raise questions about the strength (and possibly the universality) of this selective force in shaping S. cerevisiae’s proteome.
Citation InformationDouglas W. Raiford, Esley M. Heizer, Robert V. Miller, Hiroshi Akashi, et al.. "Do Amino Acid Biosynthetic Costs Constrain Protein Evolution in Saccharomyces cerevisiae?" Journal of Molecular Evolution Vol. 67 Iss. 6 (2008) p. 621 - 630 ISSN: 00222844
Available at: http://works.bepress.com/michael_raymer/48/