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Article
Reduced mitochondrial efficiency explains mismatched growth and metabolic rate at supraoptimal temperatures.
Faculty Scholarship
  • Eloy Martinez, Virginia Commonwealth University
  • Michael A. Menze, University of Louisville
  • Salvatore J. Agosta, Virginia Commonwealth University
Document Type
Article
Publication Date
3-1-2017
Department
Biology
Disciplines
Abstract
The relationship between whole-organism growth and metabolism is generally assumed to be positive and causative; higher metabolic rates support higher growth rates. In Manduca sexta, existing data demonstrate a deviation from this simple prediction: at supraoptimal temperatures for larval growth, metabolic rate keeps increasing while growth rate is decreasing. This mismatch presumably reflects the rising “cost of maintenance” with temperature. Precisely what constitutes this cost is not clear, but we suspect the efficiency with which mitochondria harness oxygen and organic substrates into cellular energy (ATP) is key. We tested this by integrating existing data on M. sexta growth and metabolism with new data on mitochondrial bioenergetics across the temperature range 14°–42°C. Across this range, our measure of mitochondrial efficiency closely paralleled larval growth rates. At supraoptimal temperatures for growth, mitochondrial efficiency was reduced, which could explain the mismatch between growth and metabolism observed at the whole-organism level.
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Copyright 2017 by The University of Chicago. All rights reserved.

DOI
10.1086/689871
Citation Information

Martinez, Eloy, Michael A. Menze, and Salvatore J. Agosta. "Reduced Mitochondrial Efficiency Explains Mismatched Growth and Metabolic Rate at Supraoptimal Temperatures." 2017. Physiological and Biochemical Zoology 90(2): 294-298.