Skip to main content
Cell Population Modelling of Yeast Glycolytic Oscillations
Biochemical Journal (2002)
  • Michael A Henson, University of Massachusetts - Amherst
  • Dirk Muller
  • Matthias Reuss
We investigated a cell-population modelling technique in which the population is constructed from an ensemble of individual cell models. The average value or the number distribution of any intracellular property captured by the individual cell model can be calculated by simulation of a sufficient number of individual cells. The proposed method is applied to a simple model of yeast glycolytic oscillations where synchronization of the cell population is mediated by the action of an excreted metabolite. We show that smooth one-dimensional distributions can be obtained with ensembles comprising 1000 individual cells. Random variations in the state and}or structure of individual cells are shown to produce complex dynamic behaviours which cannot be adequately captured by small ensembles.
  • cell-ensemble model,
  • cell population dynamics,
  • oscillatory dynamics,
  • synchronization
Publication Date
December 1, 2002
Publisher Statement
DOI: 10.1042/BJ20021051
Citation Information
Michael A Henson, Dirk Muller and Matthias Reuss. "Cell Population Modelling of Yeast Glycolytic Oscillations" Biochemical Journal Vol. 368 (2002)
Available at: